Cystitis Research Today is a free monthly online journal that collates and summarizes the latest research about Cystitis, including details on urinary tract infections, causes, treatment, prevention.

Intravesical ozone therapy for progressive radiation-induced hematuria.

Clavo B, Gutiérrez D, Martín D, Suárez G, Hernández MA, Robaina F

Department of Radiation Oncology, Research Unit, Dr. Negrin University Hospital, Las Palmas, Spain. bernardinoclavo@terra.es

BACKGROUND: Progressive radiation-induced cystitis can become a serious clinical problem the therapeutic solution of which is limited and almost invariably aggressive. Ozone therapy is a nonconventional therapy that has been reported to offer benefits in late-onset wound healing and ischemic disorders. This report describes a patient with progressive radiation-induced hematuria from standard conservative treatment that was further treated with ozone therapy. METHOD: Ozone therapy was achieved by intravesical instillation of ozonized bi-distilled water over a period of 30 minutes, three sessions per week during the first weeks. Later, ozone therapy sessions were decreased and involved ozonized water or direct intravesicular instillation of ozone at 20-25 microg/mL. RESULTS: Hematuria was successfully controlled by intravesical application of ozone therapy. CONCLUSIONS: The successes achieved with this technique suggest that intravesicular instillation of ozonized bi-distilled water or ozone merits further investigation with a view to its application to counter this radiation-induced side-effect.

Published 4 July 2005 in J Altern Complement Med, 11(3): 539-41.
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